ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.
Identifieur interne : 000831 ( Main/Exploration ); précédent : 000830; suivant : 000832ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.
Auteurs : Ivan T. Lee [États-Unis] ; Tsuguhisa Nakayama [États-Unis, Japon] ; Chien-Ting Wu [États-Unis] ; Yury Goltsev [États-Unis] ; Sizun Jiang [États-Unis] ; Phillip A. Gall [États-Unis] ; Chun-Kang Liao [Taïwan] ; Liang-Chun Shih [Taïwan] ; Christian M. Schürch [États-Unis] ; David R. Mcilwain [États-Unis] ; Pauline Chu [États-Unis] ; Nicole A. Borchard [États-Unis] ; David Zarabanda [États-Unis] ; Sachi S. Dholakia [États-Unis] ; Angela Yang [États-Unis] ; Dayoung Kim [États-Unis] ; Han Chen [États-Unis] ; Tomoharu Kanie [États-Unis] ; Chia-Der Lin [Taïwan] ; Ming-Hsui Tsai [Taïwan] ; Katie M. Phillips [États-Unis] ; Raymond Kim [États-Unis] ; Jonathan B. Overdevest [États-Unis] ; Matthew A. Tyler [États-Unis] ; Carol H. Yan [États-Unis] ; Chih-Feng Lin [Taïwan] ; Yi-Tsen Lin [Taïwan] ; Da-Tian Bau [Taïwan] ; Gregory J. Tsay [Taïwan] ; Zara M. Patel [États-Unis] ; Yung-An Tsou [Taïwan] ; Alexandar Tzankov [Suisse] ; Matthias S. Matter [Suisse] ; Chih-Jaan Tai [Taïwan] ; Te-Huei Yeh [Taïwan] ; Peter H. Hwang [États-Unis] ; Garry P. Nolan [États-Unis] ; Jayakar V. Nayak [États-Unis] ; Peter K. Jackson [États-Unis]Source :
- Nature communications [ 2041-1723 ] ; 2020.
Descripteurs français
- KwdFr :
- Antagonistes des récepteurs aux angiotensines (usage thérapeutique), Appareil respiratoire (anatomopathologie), Appareil respiratoire (métabolisme), Appareil respiratoire (virologie), Cellules caliciformes (métabolisme), Cellules endothéliales (MeSH), Cils vibratiles (métabolisme), Expression des gènes (effets des médicaments et des substances chimiques), Facteurs sexuels (MeSH), Facteurs âges (MeSH), Fumer (MeSH), Humains (MeSH), Infections à coronavirus (anatomopathologie), Infections à coronavirus (virologie), Inhibiteurs de l'enzyme de conversion de l'angiotensine (usage thérapeutique), Pandémies (MeSH), Peptidyl-Dipeptidase A (génétique), Peptidyl-Dipeptidase A (métabolisme), Pneumopathie virale (anatomopathologie), Pneumopathie virale (virologie), Poumon (anatomopathologie), Sinusite (métabolisme).
- MESH :
- anatomopathologie : Appareil respiratoire, Infections à coronavirus, Pneumopathie virale, Poumon.
- effets des médicaments et des substances chimiques : Expression des gènes.
- génétique : Peptidyl-Dipeptidase A.
- métabolisme : Appareil respiratoire, Cellules caliciformes, Cils vibratiles, Peptidyl-Dipeptidase A, Sinusite.
- usage thérapeutique : Antagonistes des récepteurs aux angiotensines, Inhibiteurs de l'enzyme de conversion de l'angiotensine.
- virologie : Appareil respiratoire, Infections à coronavirus, Pneumopathie virale.
- Cellules endothéliales, Facteurs sexuels, Facteurs âges, Fumer, Humains, Pandémies.
English descriptors
- KwdEn :
- Age Factors (MeSH), Angiotensin Receptor Antagonists (therapeutic use), Angiotensin-Converting Enzyme 2 (MeSH), Angiotensin-Converting Enzyme Inhibitors (therapeutic use), COVID-19 (MeSH), Cilia (metabolism), Coronavirus Infections (pathology), Coronavirus Infections (virology), Endothelial Cells (MeSH), Gene Expression (drug effects), Goblet Cells (metabolism), Humans (MeSH), Lung (pathology), Pandemics (MeSH), Peptidyl-Dipeptidase A (genetics), Peptidyl-Dipeptidase A (metabolism), Pneumonia, Viral (pathology), Pneumonia, Viral (virology), Respiratory System (metabolism), Respiratory System (pathology), Respiratory System (virology), Sex Factors (MeSH), Sinusitis (metabolism), Smoking (MeSH).
- MESH :
- chemical , genetics : Peptidyl-Dipeptidase A.
- chemical , metabolism : Peptidyl-Dipeptidase A.
- chemical , therapeutic use : Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors.
- drug effects : Gene Expression.
- metabolism : Cilia, Goblet Cells, Respiratory System, Sinusitis.
- pathology : Coronavirus Infections, Lung, Pneumonia, Viral, Respiratory System.
- virology : Coronavirus Infections, Pneumonia, Viral, Respiratory System.
- Age Factors, Angiotensin-Converting Enzyme 2, COVID-19, Endothelial Cells, Humans, Pandemics, Sex Factors, Smoking.
Abstract
The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the pathogenesis of SARS-CoV-2. We investigate the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of human donors using a diverse panel of banked tissues. Here, we report our discovery that the ACE2 receptor protein robustly localizes within the motile cilia of airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during host respiratory transmission. We further determine whether ciliary ACE2 expression in the upper airway is influenced by patient demographics, clinical characteristics, comorbidities, or medication use, and show the first mechanistic evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) does not increase susceptibility to SARS-CoV-2 infection through enhancing the expression of ciliary ACE2 receptor. These findings are crucial to our understanding of the transmission of SARS-CoV-2 for prevention and control of this virulent pathogen.
DOI: 10.1038/s41467-020-19145-6
PubMed: 33116139
PubMed Central: PMC7595232
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.</title><author><name sortKey="Lee, Ivan T" sort="Lee, Ivan T" uniqKey="Lee I" first="Ivan T" last="Lee">Ivan T. Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nakayama, Tsuguhisa" sort="Nakayama, Tsuguhisa" uniqKey="Nakayama T" first="Tsuguhisa" last="Nakayama">Tsuguhisa Nakayama</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Wu, Chien Ting" sort="Wu, Chien Ting" uniqKey="Wu C" first="Chien-Ting" last="Wu">Chien-Ting Wu</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Goltsev, Yury" sort="Goltsev, Yury" uniqKey="Goltsev Y" first="Yury" last="Goltsev">Yury Goltsev</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Sizun" sort="Jiang, Sizun" uniqKey="Jiang S" first="Sizun" last="Jiang">Sizun Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Gall, Phillip A" sort="Gall, Phillip A" uniqKey="Gall P" first="Phillip A" last="Gall">Phillip A. Gall</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Liao, Chun Kang" sort="Liao, Chun Kang" uniqKey="Liao C" first="Chun-Kang" last="Liao">Chun-Kang Liao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Shih, Liang Chun" sort="Shih, Liang Chun" uniqKey="Shih L" first="Liang-Chun" last="Shih">Liang-Chun Shih</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Schurch, Christian M" sort="Schurch, Christian M" uniqKey="Schurch C" first="Christian M" last="Schürch">Christian M. Schürch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Mcilwain, David R" sort="Mcilwain, David R" uniqKey="Mcilwain D" first="David R" last="Mcilwain">David R. Mcilwain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Pauline" sort="Chu, Pauline" uniqKey="Chu P" first="Pauline" last="Chu">Pauline Chu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Borchard, Nicole A" sort="Borchard, Nicole A" uniqKey="Borchard N" first="Nicole A" last="Borchard">Nicole A. Borchard</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zarabanda, David" sort="Zarabanda, David" uniqKey="Zarabanda D" first="David" last="Zarabanda">David Zarabanda</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dholakia, Sachi S" sort="Dholakia, Sachi S" uniqKey="Dholakia S" first="Sachi S" last="Dholakia">Sachi S. Dholakia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yang, Angela" sort="Yang, Angela" uniqKey="Yang A" first="Angela" last="Yang">Angela Yang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Dayoung" sort="Kim, Dayoung" uniqKey="Kim D" first="Dayoung" last="Kim">Dayoung Kim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, Han" sort="Chen, Han" uniqKey="Chen H" first="Han" last="Chen">Han Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Kanie, Tomoharu" sort="Kanie, Tomoharu" uniqKey="Kanie T" first="Tomoharu" last="Kanie">Tomoharu Kanie</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lin, Chia Der" sort="Lin, Chia Der" uniqKey="Lin C" first="Chia-Der" last="Lin">Chia-Der Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ming Hsui" sort="Tsai, Ming Hsui" uniqKey="Tsai M" first="Ming-Hsui" last="Tsai">Ming-Hsui Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, Katie M" sort="Phillips, Katie M" uniqKey="Phillips K" first="Katie M" last="Phillips">Katie M. Phillips</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Raymond" sort="Kim, Raymond" uniqKey="Kim R" first="Raymond" last="Kim">Raymond Kim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Overdevest, Jonathan B" sort="Overdevest, Jonathan B" uniqKey="Overdevest J" first="Jonathan B" last="Overdevest">Jonathan B. Overdevest</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Tyler, Matthew A" sort="Tyler, Matthew A" uniqKey="Tyler M" first="Matthew A" last="Tyler">Matthew A. Tyler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Yan, Carol H" sort="Yan, Carol H" uniqKey="Yan C" first="Carol H" last="Yan">Carol H. Yan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lin, Chih Feng" sort="Lin, Chih Feng" uniqKey="Lin C" first="Chih-Feng" last="Lin">Chih-Feng Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yi Tsen" sort="Lin, Yi Tsen" uniqKey="Lin Y" first="Yi-Tsen" last="Lin">Yi-Tsen Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Bau, Da Tian" sort="Bau, Da Tian" uniqKey="Bau D" first="Da-Tian" last="Bau">Da-Tian Bau</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tsay, Gregory J" sort="Tsay, Gregory J" uniqKey="Tsay G" first="Gregory J" last="Tsay">Gregory J. Tsay</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Zara M" sort="Patel, Zara M" uniqKey="Patel Z" first="Zara M" last="Patel">Zara M. Patel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tsou, Yung An" sort="Tsou, Yung An" uniqKey="Tsou Y" first="Yung-An" last="Tsou">Yung-An Tsou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tzankov, Alexandar" sort="Tzankov, Alexandar" uniqKey="Tzankov A" first="Alexandar" last="Tzankov">Alexandar Tzankov</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Matter, Matthias S" sort="Matter, Matthias S" uniqKey="Matter M" first="Matthias S" last="Matter">Matthias S. Matter</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tai, Chih Jaan" sort="Tai, Chih Jaan" uniqKey="Tai C" first="Chih-Jaan" last="Tai">Chih-Jaan Tai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Yeh, Te Huei" sort="Yeh, Te Huei" uniqKey="Yeh T" first="Te-Huei" last="Yeh">Te-Huei Yeh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hwang, Peter H" sort="Hwang, Peter H" uniqKey="Hwang P" first="Peter H" last="Hwang">Peter H. Hwang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nolan, Garry P" sort="Nolan, Garry P" uniqKey="Nolan G" first="Garry P" last="Nolan">Garry P. Nolan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA. gnolan@stanford.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Nayak, Jayakar V" sort="Nayak, Jayakar V" uniqKey="Nayak J" first="Jayakar V" last="Nayak">Jayakar V. Nayak</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jackson, Peter K" sort="Jackson, Peter K" uniqKey="Jackson P" first="Peter K" last="Jackson">Peter K. Jackson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020</date><idno type="RBID">pubmed:33116139</idno><idno type="pmid">33116139</idno><idno type="doi">10.1038/s41467-020-19145-6</idno><idno type="pmc">PMC7595232</idno><idno type="wicri:Area/Main/Corpus">000214</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000214</idno><idno type="wicri:Area/Main/Curation">000214</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000214</idno><idno type="wicri:Area/Main/Exploration">000214</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.</title><author><name sortKey="Lee, Ivan T" sort="Lee, Ivan T" uniqKey="Lee I" first="Ivan T" last="Lee">Ivan T. Lee</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nakayama, Tsuguhisa" sort="Nakayama, Tsuguhisa" uniqKey="Nakayama T" first="Tsuguhisa" last="Nakayama">Tsuguhisa Nakayama</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="3"><nlm:affiliation>Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement><region type="région">Région de Kantō</region></placeName></affiliation></author><author><name sortKey="Wu, Chien Ting" sort="Wu, Chien Ting" uniqKey="Wu C" first="Chien-Ting" last="Wu">Chien-Ting Wu</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Goltsev, Yury" sort="Goltsev, Yury" uniqKey="Goltsev Y" first="Yury" last="Goltsev">Yury Goltsev</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Jiang, Sizun" sort="Jiang, Sizun" uniqKey="Jiang S" first="Sizun" last="Jiang">Sizun Jiang</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Gall, Phillip A" sort="Gall, Phillip A" uniqKey="Gall P" first="Phillip A" last="Gall">Phillip A. Gall</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Liao, Chun Kang" sort="Liao, Chun Kang" uniqKey="Liao C" first="Chun-Kang" last="Liao">Chun-Kang Liao</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Shih, Liang Chun" sort="Shih, Liang Chun" uniqKey="Shih L" first="Liang-Chun" last="Shih">Liang-Chun Shih</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Schurch, Christian M" sort="Schurch, Christian M" uniqKey="Schurch C" first="Christian M" last="Schürch">Christian M. Schürch</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Mcilwain, David R" sort="Mcilwain, David R" uniqKey="Mcilwain D" first="David R" last="Mcilwain">David R. Mcilwain</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Chu, Pauline" sort="Chu, Pauline" uniqKey="Chu P" first="Pauline" last="Chu">Pauline Chu</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Borchard, Nicole A" sort="Borchard, Nicole A" uniqKey="Borchard N" first="Nicole A" last="Borchard">Nicole A. Borchard</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Zarabanda, David" sort="Zarabanda, David" uniqKey="Zarabanda D" first="David" last="Zarabanda">David Zarabanda</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Dholakia, Sachi S" sort="Dholakia, Sachi S" uniqKey="Dholakia S" first="Sachi S" last="Dholakia">Sachi S. Dholakia</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Yang, Angela" sort="Yang, Angela" uniqKey="Yang A" first="Angela" last="Yang">Angela Yang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Dayoung" sort="Kim, Dayoung" uniqKey="Kim D" first="Dayoung" last="Kim">Dayoung Kim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Chen, Han" sort="Chen, Han" uniqKey="Chen H" first="Han" last="Chen">Han Chen</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Kanie, Tomoharu" sort="Kanie, Tomoharu" uniqKey="Kanie T" first="Tomoharu" last="Kanie">Tomoharu Kanie</name><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lin, Chia Der" sort="Lin, Chia Der" uniqKey="Lin C" first="Chia-Der" last="Lin">Chia-Der Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tsai, Ming Hsui" sort="Tsai, Ming Hsui" uniqKey="Tsai M" first="Ming-Hsui" last="Tsai">Ming-Hsui Tsai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Phillips, Katie M" sort="Phillips, Katie M" uniqKey="Phillips K" first="Katie M" last="Phillips">Katie M. Phillips</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Kim, Raymond" sort="Kim, Raymond" uniqKey="Kim R" first="Raymond" last="Kim">Raymond Kim</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Overdevest, Jonathan B" sort="Overdevest, Jonathan B" uniqKey="Overdevest J" first="Jonathan B" last="Overdevest">Jonathan B. Overdevest</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Tyler, Matthew A" sort="Tyler, Matthew A" uniqKey="Tyler M" first="Matthew A" last="Tyler">Matthew A. Tyler</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, MN, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, MN</wicri:regionArea><placeName><region type="state">Minnesota</region></placeName></affiliation></author><author><name sortKey="Yan, Carol H" sort="Yan, Carol H" uniqKey="Yan C" first="Carol H" last="Yan">Carol H. Yan</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Lin, Chih Feng" sort="Lin, Chih Feng" uniqKey="Lin C" first="Chih-Feng" last="Lin">Chih-Feng Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yi Tsen" sort="Lin, Yi Tsen" uniqKey="Lin Y" first="Yi-Tsen" last="Lin">Yi-Tsen Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Bau, Da Tian" sort="Bau, Da Tian" uniqKey="Bau D" first="Da-Tian" last="Bau">Da-Tian Bau</name><affiliation wicri:level="1"><nlm:affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Graduate Institute of Biomedical Sciences, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tsay, Gregory J" sort="Tsay, Gregory J" uniqKey="Tsay G" first="Gregory J" last="Tsay">Gregory J. Tsay</name><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Patel, Zara M" sort="Patel, Zara M" uniqKey="Patel Z" first="Zara M" last="Patel">Zara M. Patel</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tsou, Yung An" sort="Tsou, Yung An" uniqKey="Tsou Y" first="Yung-An" last="Tsou">Yung-An Tsou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Tzankov, Alexandar" sort="Tzankov, Alexandar" uniqKey="Tzankov A" first="Alexandar" last="Tzankov">Alexandar Tzankov</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Matter, Matthias S" sort="Matter, Matthias S" uniqKey="Matter M" first="Matthias S" last="Matter">Matthias S. Matter</name><affiliation wicri:level="1"><nlm:affiliation>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel</wicri:regionArea><wicri:noRegion>Basel</wicri:noRegion></affiliation></author><author><name sortKey="Tai, Chih Jaan" sort="Tai, Chih Jaan" uniqKey="Tai C" first="Chih-Jaan" last="Tai">Chih-Jaan Tai</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otorhinolaryngology, China Medical University Hospital, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Medicine, China Medical University, Taichung</wicri:regionArea><wicri:noRegion>Taichung</wicri:noRegion></affiliation></author><author><name sortKey="Yeh, Te Huei" sort="Yeh, Te Huei" uniqKey="Yeh T" first="Te-Huei" last="Yeh">Te-Huei Yeh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Hwang, Peter H" sort="Hwang, Peter H" uniqKey="Hwang P" first="Peter H" last="Hwang">Peter H. Hwang</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Nolan, Garry P" sort="Nolan, Garry P" uniqKey="Nolan G" first="Garry P" last="Nolan">Garry P. Nolan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA. gnolan@stanford.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation></author><author><name sortKey="Nayak, Jayakar V" sort="Nayak, Jayakar V" uniqKey="Nayak J" first="Jayakar V" last="Nayak">Jayakar V. Nayak</name><affiliation wicri:level="2"><nlm:affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Jackson, Peter K" sort="Jackson, Peter K" uniqKey="Jackson P" first="Peter K" last="Jackson">Peter K. Jackson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305</wicri:regionArea><wicri:noRegion>94305</wicri:noRegion></affiliation><affiliation wicri:level="2"><nlm:affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author></analytic><series><title level="j">Nature communications</title><idno type="eISSN">2041-1723</idno><imprint><date when="2020" type="published">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age Factors (MeSH)</term><term>Angiotensin Receptor Antagonists (therapeutic use)</term><term>Angiotensin-Converting Enzyme 2 (MeSH)</term><term>Angiotensin-Converting Enzyme Inhibitors (therapeutic use)</term><term>COVID-19 (MeSH)</term><term>Cilia (metabolism)</term><term>Coronavirus Infections (pathology)</term><term>Coronavirus Infections (virology)</term><term>Endothelial Cells (MeSH)</term><term>Gene Expression (drug effects)</term><term>Goblet Cells (metabolism)</term><term>Humans (MeSH)</term><term>Lung (pathology)</term><term>Pandemics (MeSH)</term><term>Peptidyl-Dipeptidase A (genetics)</term><term>Peptidyl-Dipeptidase A (metabolism)</term><term>Pneumonia, Viral (pathology)</term><term>Pneumonia, Viral (virology)</term><term>Respiratory System (metabolism)</term><term>Respiratory System (pathology)</term><term>Respiratory System (virology)</term><term>Sex Factors (MeSH)</term><term>Sinusitis (metabolism)</term><term>Smoking (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antagonistes des récepteurs aux angiotensines (usage thérapeutique)</term><term>Appareil respiratoire (anatomopathologie)</term><term>Appareil respiratoire (métabolisme)</term><term>Appareil respiratoire (virologie)</term><term>Cellules caliciformes (métabolisme)</term><term>Cellules endothéliales (MeSH)</term><term>Cils vibratiles (métabolisme)</term><term>Expression des gènes (effets des médicaments et des substances chimiques)</term><term>Facteurs sexuels (MeSH)</term><term>Facteurs âges (MeSH)</term><term>Fumer (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (anatomopathologie)</term><term>Infections à coronavirus (virologie)</term><term>Inhibiteurs de l'enzyme de conversion de l'angiotensine (usage thérapeutique)</term><term>Pandémies (MeSH)</term><term>Peptidyl-Dipeptidase A (génétique)</term><term>Peptidyl-Dipeptidase A (métabolisme)</term><term>Pneumopathie virale (anatomopathologie)</term><term>Pneumopathie virale (virologie)</term><term>Poumon (anatomopathologie)</term><term>Sinusite (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Angiotensin Receptor Antagonists</term><term>Angiotensin-Converting Enzyme Inhibitors</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression</term></keywords><keywords scheme="MESH" qualifier="effets des médicaments et des substances chimiques" xml:lang="fr"><term>Expression des gènes</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Peptidyl-Dipeptidase A</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cilia</term><term>Goblet Cells</term><term>Respiratory System</term><term>Sinusitis</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Appareil respiratoire</term><term>Cellules caliciformes</term><term>Cils vibratiles</term><term>Peptidyl-Dipeptidase A</term><term>Sinusite</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Coronavirus Infections</term><term>Lung</term><term>Pneumonia, Viral</term><term>Respiratory System</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antagonistes des récepteurs aux angiotensines</term><term>Inhibiteurs de l'enzyme de conversion de l'angiotensine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Appareil respiratoire</term><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term><term>Respiratory System</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Age Factors</term><term>Angiotensin-Converting Enzyme 2</term><term>COVID-19</term><term>Endothelial Cells</term><term>Humans</term><term>Pandemics</term><term>Sex Factors</term><term>Smoking</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules endothéliales</term><term>Facteurs sexuels</term><term>Facteurs âges</term><term>Fumer</term><term>Humains</term><term>Pandémies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the pathogenesis of SARS-CoV-2. We investigate the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of human donors using a diverse panel of banked tissues. Here, we report our discovery that the ACE2 receptor protein robustly localizes within the motile cilia of airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during host respiratory transmission. We further determine whether ciliary ACE2 expression in the upper airway is influenced by patient demographics, clinical characteristics, comorbidities, or medication use, and show the first mechanistic evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) does not increase susceptibility to SARS-CoV-2 infection through enhancing the expression of ciliary ACE2 receptor. These findings are crucial to our understanding of the transmission of SARS-CoV-2 for prevention and control of this virulent pathogen.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">33116139</PMID><DateCompleted><Year>2020</Year><Month>11</Month><Day>03</Day></DateCompleted><DateRevised><Year>2020</Year><Month>12</Month><Day>18</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2041-1723</ISSN><JournalIssue CitedMedium="Internet"><Volume>11</Volume><Issue>1</Issue><PubDate><Year>2020</Year><Month>10</Month><Day>28</Day></PubDate></JournalIssue><Title>Nature communications</Title><ISOAbbreviation>Nat Commun</ISOAbbreviation></Journal><ArticleTitle>ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.</ArticleTitle><Pagination><MedlinePgn>5453</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1038/s41467-020-19145-6</ELocationID><Abstract><AbstractText>The coronavirus SARS-CoV-2 is the causative agent of the ongoing severe acute respiratory disease pandemic COVID-19. Tissue and cellular tropism is one key to understanding the pathogenesis of SARS-CoV-2. We investigate the expression and subcellular localization of the SARS-CoV-2 receptor, angiotensin-converting enzyme 2 (ACE2), within the upper (nasal) and lower (pulmonary) respiratory tracts of human donors using a diverse panel of banked tissues. Here, we report our discovery that the ACE2 receptor protein robustly localizes within the motile cilia of airway epithelial cells, which likely represents the initial or early subcellular site of SARS-CoV-2 viral entry during host respiratory transmission. We further determine whether ciliary ACE2 expression in the upper airway is influenced by patient demographics, clinical characteristics, comorbidities, or medication use, and show the first mechanistic evidence that the use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin II receptor blockers (ARBs) does not increase susceptibility to SARS-CoV-2 infection through enhancing the expression of ciliary ACE2 receptor. These findings are crucial to our understanding of the transmission of SARS-CoV-2 for prevention and control of this virulent pathogen.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Ivan T</ForeName><Initials>IT</Initials><Identifier Source="ORCID">0000-0002-5446-2046</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nakayama</LastName><ForeName>Tsuguhisa</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, Jikei University School of Medicine, Tokyo, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Chien-Ting</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goltsev</LastName><ForeName>Yury</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jiang</LastName><ForeName>Sizun</ForeName><Initials>S</Initials><Identifier Source="ORCID">0000-0001-6149-3142</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gall</LastName><ForeName>Phillip A</ForeName><Initials>PA</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Chun-Kang</ForeName><Initials>CK</Initials><Identifier Source="ORCID">0000-0002-0037-1421</Identifier><AffiliationInfo><Affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shih</LastName><ForeName>Liang-Chun</ForeName><Initials>LC</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schürch</LastName><ForeName>Christian M</ForeName><Initials>CM</Initials><Identifier Source="ORCID">0000-0002-1792-1768</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>McIlwain</LastName><ForeName>David R</ForeName><Initials>DR</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chu</LastName><ForeName>Pauline</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Borchard</LastName><ForeName>Nicole A</ForeName><Initials>NA</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zarabanda</LastName><ForeName>David</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dholakia</LastName><ForeName>Sachi S</ForeName><Initials>SS</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yang</LastName><ForeName>Angela</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Dayoung</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Han</ForeName><Initials>H</Initials><Identifier Source="ORCID">0000-0002-1722-8736</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kanie</LastName><ForeName>Tomoharu</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Chia-Der</ForeName><Initials>CD</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsai</LastName><ForeName>Ming-Hsui</ForeName><Initials>MH</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Phillips</LastName><ForeName>Katie M</ForeName><Initials>KM</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Raymond</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Overdevest</LastName><ForeName>Jonathan B</ForeName><Initials>JB</Initials><Identifier Source="ORCID">0000-0002-1152-2512</Identifier><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Columbia University School of Medicine, New York City, NY, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tyler</LastName><ForeName>Matthew A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, University of Minnesota School of Medicine, Minneapolis, MN, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yan</LastName><ForeName>Carol H</ForeName><Initials>CH</Initials><Identifier Source="ORCID">0000-0003-1934-4922</Identifier><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, University of California San Diego School of Medicine, San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Chih-Feng</ForeName><Initials>CF</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Yi-Tsen</ForeName><Initials>YT</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bau</LastName><ForeName>Da-Tian</ForeName><Initials>DT</Initials><AffiliationInfo><Affiliation>Graduate Institute of Biomedical Sciences, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Terry Fox Cancer Research Laboratory, Translational Medicine Center, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsay</LastName><ForeName>Gregory J</ForeName><Initials>GJ</Initials><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Zara M</ForeName><Initials>ZM</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsou</LastName><ForeName>Yung-An</ForeName><Initials>YA</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tzankov</LastName><ForeName>Alexandar</ForeName><Initials>A</Initials><Identifier Source="ORCID">0000-0002-1100-3819</Identifier><AffiliationInfo><Affiliation>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Matter</LastName><ForeName>Matthias S</ForeName><Initials>MS</Initials><Identifier Source="ORCID">0000-0002-2005-5266</Identifier><AffiliationInfo><Affiliation>Pathology, Institute of Medical Genetics and Pathology, University Hospital Basel, University of Basel, Basel, Switzerland.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tai</LastName><ForeName>Chih-Jaan</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Otorhinolaryngology, China Medical University Hospital, Taichung, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>School of Medicine, China Medical University, Taichung, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yeh</LastName><ForeName>Te-Huei</ForeName><Initials>TH</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Department of Otolaryngology, College of Medicine, National Taiwan University, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hwang</LastName><ForeName>Peter H</ForeName><Initials>PH</Initials><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nolan</LastName><ForeName>Garry P</ForeName><Initials>GP</Initials><Identifier Source="ORCID">0000-0002-8862-9043</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA. gnolan@stanford.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Nayak</LastName><ForeName>Jayakar V</ForeName><Initials>JV</Initials><Identifier Source="ORCID">0000-0003-4454-0861</Identifier><AffiliationInfo><Affiliation>Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jackson</LastName><ForeName>Peter K</ForeName><Initials>PK</Initials><Identifier Source="ORCID">0000-0002-1742-2539</Identifier><AffiliationInfo><Affiliation>Department of Pathology, Stanford University School of Medicine, Stanford, CA, 94305, USA.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Baxter Laboratory, Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA, USA.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DSTL/AGR00980</GrantID><Acronym>FD</Acronym><Agency>FDA HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HHSF223201610018C </GrantID><Acronym>FD</Acronym><Agency>FDA HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>HR001118S0037-PREPARE-FP-001</GrantID><Agency>Defense Advanced Research Project Agency</Agency><Country>International</Country></Grant><Grant><GrantID>U54 CA209971</GrantID><Acronym>CA</Acronym><Agency>NCI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>P30 DK116074</GrantID><Acronym>DK</Acronym><Agency>NIDDK NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 AI149672</GrantID><Acronym>AI</Acronym><Agency>NIAID NIH HHS</Agency><Country>United States</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D052061">Research Support, N.I.H., Extramural</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D013487">Research Support, U.S. Gov't, P.H.S.</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Nat Commun</MedlineTA><NlmUniqueID>101528555</NlmUniqueID><ISSNLinking>2041-1723</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D057911">Angiotensin Receptor Antagonists</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000806">Angiotensin-Converting Enzyme Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.15.1</RegistryNumber><NameOfSubstance UI="D007703">Peptidyl-Dipeptidase A</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.23</RegistryNumber><NameOfSubstance UI="C000705307">ACE2 protein, human</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.4.17.23</RegistryNumber><NameOfSubstance UI="D000085962">Angiotensin-Converting Enzyme 2</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><CommentsCorrectionsList><CommentsCorrections RefType="UpdateOf"><RefSource>medRxiv. 2020 May 12;:</RefSource><PMID Version="1">32511516</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName UI="D000367" MajorTopicYN="N">Age Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D057911" MajorTopicYN="N">Angiotensin Receptor Antagonists</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000085962" MajorTopicYN="N">Angiotensin-Converting Enzyme 2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000806" MajorTopicYN="N">Angiotensin-Converting Enzyme Inhibitors</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002923" MajorTopicYN="N">Cilia</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D042783" MajorTopicYN="N">Endothelial Cells</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015870" MajorTopicYN="N">Gene Expression</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D020397" MajorTopicYN="N">Goblet Cells</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008168" MajorTopicYN="N">Lung</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="N">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007703" MajorTopicYN="N">Peptidyl-Dipeptidase A</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="Y">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012137" MajorTopicYN="N">Respiratory System</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000821" MajorTopicYN="N">virology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012737" MajorTopicYN="N">Sex Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012852" MajorTopicYN="N">Sinusitis</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012907" MajorTopicYN="N">Smoking</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>05</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>09</Month><Day>30</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>10</Month><Day>29</Day><Hour>5</Hour><Minute>42</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>10</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>11</Month><Day>4</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33116139</ArticleId><ArticleId IdType="doi">10.1038/s41467-020-19145-6</ArticleId><ArticleId IdType="pii">10.1038/s41467-020-19145-6</ArticleId><ArticleId IdType="pmc">PMC7595232</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Lancet. 2020 May 30;395(10238):1705-1714</Citation><ArticleIdList><ArticleId IdType="pubmed">32416785</ArticleId></ArticleIdList></Reference><Reference><Citation>J Pathol. 2004 Jun;203(2):631-7</Citation><ArticleIdList><ArticleId IdType="pubmed">15141377</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2020 May 21;526(1):135-140</Citation><ArticleIdList><ArticleId IdType="pubmed">32199615</ArticleId></ArticleIdList></Reference><Reference><Citation>Mol Syst Biol. 2020 Jul;16(7):e9610</Citation><ArticleIdList><ArticleId IdType="pubmed">32715618</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 Apr;8(4):e21</Citation><ArticleIdList><ArticleId IdType="pubmed">32171062</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2020 Aug;26(8):1205-1211</Citation><ArticleIdList><ArticleId IdType="pubmed">32546824</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Dec;79(24):15511-24</Citation><ArticleIdList><ArticleId IdType="pubmed">16306622</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2020 Mar;579(7798):270-273</Citation><ArticleIdList><ArticleId IdType="pubmed">32015507</ArticleId></ArticleIdList></Reference><Reference><Citation>Lancet Respir Med. 2020 Jul;8(7):687-695</Citation><ArticleIdList><ArticleId IdType="pubmed">32386571</ArticleId></ArticleIdList></Reference><Reference><Citation>J Travel Med. 2020 May 18;27(3):</Citation><ArticleIdList><ArticleId IdType="pubmed">32186711</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Jun 18;382(25):2441-2448</Citation><ArticleIdList><ArticleId IdType="pubmed">32356628</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2019 Jul 30;93(16):</Citation><ArticleIdList><ArticleId IdType="pubmed">31167913</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2015 Jun 24;10(6):e0130517</Citation><ArticleIdList><ArticleId IdType="pubmed">26107373</ArticleId></ArticleIdList></Reference><Reference><Citation>FEBS Lett. 2002 Dec 4;532(1-2):107-10</Citation><ArticleIdList><ArticleId IdType="pubmed">12459472</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Apr 28;323(16):1574-1581</Citation><ArticleIdList><ArticleId IdType="pubmed">32250385</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Mar 17;323(11):1061-1069</Citation><ArticleIdList><ArticleId IdType="pubmed">32031570</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2019 Oct 15;93(21):</Citation><ArticleIdList><ArticleId IdType="pubmed">31391268</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2002 Jun;76(11):5654-66</Citation><ArticleIdList><ArticleId IdType="pubmed">11991994</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2005 Jan;79(2):1113-24</Citation><ArticleIdList><ArticleId IdType="pubmed">15613339</ArticleId></ArticleIdList></Reference><Reference><Citation>EBioMedicine. 2020 Oct;60:102976</Citation><ArticleIdList><ArticleId IdType="pubmed">32971472</ArticleId></ArticleIdList></Reference><Reference><Citation>J Virol. 2006 Aug;80(16):8060-8</Citation><ArticleIdList><ArticleId IdType="pubmed">16873262</ArticleId></ArticleIdList></Reference><Reference><Citation>Hypertension. 2019 Oct;74(4):817-825</Citation><ArticleIdList><ArticleId IdType="pubmed">31422694</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2020 May 28;181(5):1016-1035.e19</Citation><ArticleIdList><ArticleId IdType="pubmed">32413319</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Hypertens. 2015 Jan;28(1):15-21</Citation><ArticleIdList><ArticleId IdType="pubmed">24842388</ArticleId></ArticleIdList></Reference><Reference><Citation>Int J Cardiol. 2016 Jul 15;215:114-9</Citation><ArticleIdList><ArticleId IdType="pubmed">27111172</ArticleId></ArticleIdList></Reference><Reference><Citation>Circ Res. 2016 Apr 15;118(8):1313-26</Citation><ArticleIdList><ArticleId IdType="pubmed">27081112</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA. 2020 Jul 14;324(2):168-177</Citation><ArticleIdList><ArticleId IdType="pubmed">32558877</ArticleId></ArticleIdList></Reference><Reference><Citation>MMWR Morb Mortal Wkly Rep. 2020 Apr 03;69(13):382-386</Citation><ArticleIdList><ArticleId IdType="pubmed">32240123</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2012;7(4):e35876</Citation><ArticleIdList><ArticleId IdType="pubmed">22558251</ArticleId></ArticleIdList></Reference><Reference><Citation>Science. 2020 May 29;368(6494):1012-1015</Citation><ArticleIdList><ArticleId IdType="pubmed">32303590</ArticleId></ArticleIdList></Reference><Reference><Citation>Circulation. 2005 May 24;111(20):2605-10</Citation><ArticleIdList><ArticleId IdType="pubmed">15897343</ArticleId></ArticleIdList></Reference><Reference><Citation>PLoS One. 2009 Dec 16;4(12):e8157</Citation><ArticleIdList><ArticleId IdType="pubmed">20016779</ArticleId></ArticleIdList></Reference><Reference><Citation>Biochem Biophys Res Commun. 2004 Jul 9;319(4):1216-21</Citation><ArticleIdList><ArticleId IdType="pubmed">15194496</ArticleId></ArticleIdList></Reference><Reference><Citation>BMJ. 2020 Feb 28;368:m810</Citation><ArticleIdList><ArticleId IdType="pubmed">32111649</ArticleId></ArticleIdList></Reference><Reference><Citation>Am J Physiol Renal Physiol. 2009 Feb;296(2):F398-405</Citation><ArticleIdList><ArticleId IdType="pubmed">19004932</ArticleId></ArticleIdList></Reference><Reference><Citation>J Am Heart Assoc. 2020 Apr 7;9(7):e016219</Citation><ArticleIdList><ArticleId IdType="pubmed">32233755</ArticleId></ArticleIdList></Reference><Reference><Citation>N Engl J Med. 2020 Jun 18;382(25):2431-2440</Citation><ArticleIdList><ArticleId IdType="pubmed">32356627</ArticleId></ArticleIdList></Reference><Reference><Citation>Histopathology. 2020 May 4;:</Citation><ArticleIdList><ArticleId IdType="pubmed">32364264</ArticleId></ArticleIdList></Reference><Reference><Citation>JAMA Netw Open. 2020 Apr 1;3(4):e205619</Citation><ArticleIdList><ArticleId IdType="pubmed">32275319</ArticleId></ArticleIdList></Reference><Reference><Citation>Cell. 2020 Apr 16;181(2):271-280.e8</Citation><ArticleIdList><ArticleId IdType="pubmed">32142651</ArticleId></ArticleIdList></Reference><Reference><Citation>Virology. 2007 Oct 25;367(2):367-74</Citation><ArticleIdList><ArticleId IdType="pubmed">17631932</ArticleId></ArticleIdList></Reference><Reference><Citation>J Hypertens. 2020 May;38(5):781-782</Citation><ArticleIdList><ArticleId IdType="pubmed">32195824</ArticleId></ArticleIdList></Reference><Reference><Citation>Nat Med. 2020 May;26(5):681-687</Citation><ArticleIdList><ArticleId IdType="pubmed">32327758</ArticleId></ArticleIdList></Reference><Reference><Citation>Nicotine Tob Res. 2020 Aug 24;22(9):1653-1656</Citation><ArticleIdList><ArticleId IdType="pubmed">32399563</ArticleId></ArticleIdList></Reference><Reference><Citation>J Infect Dis. 2018 Mar 5;217(6):906-915</Citation><ArticleIdList><ArticleId IdType="pubmed">29228279</ArticleId></ArticleIdList></Reference><Reference><Citation>Nature. 2020 Mar;579(7798):265-269</Citation><ArticleIdList><ArticleId IdType="pubmed">32015508</ArticleId></ArticleIdList></Reference></ReferenceList></PubmedData></pubmed><affiliations><list><country><li>Japon</li><li>Suisse</li><li>Taïwan</li><li>États-Unis</li></country><region><li>Californie</li><li>Minnesota</li><li>Région de Kantō</li><li>État de New York</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="États-Unis"><noRegion><name sortKey="Lee, Ivan T" sort="Lee, Ivan T" uniqKey="Lee I" first="Ivan T" last="Lee">Ivan T. Lee</name></noRegion><name sortKey="Borchard, Nicole A" sort="Borchard, Nicole A" uniqKey="Borchard N" first="Nicole A" last="Borchard">Nicole A. Borchard</name><name sortKey="Chen, Han" sort="Chen, Han" uniqKey="Chen H" first="Han" last="Chen">Han Chen</name><name sortKey="Chu, Pauline" sort="Chu, Pauline" uniqKey="Chu P" first="Pauline" last="Chu">Pauline Chu</name><name sortKey="Dholakia, Sachi S" sort="Dholakia, Sachi S" uniqKey="Dholakia S" first="Sachi S" last="Dholakia">Sachi S. Dholakia</name><name sortKey="Gall, Phillip A" sort="Gall, Phillip A" uniqKey="Gall P" first="Phillip A" last="Gall">Phillip A. Gall</name><name sortKey="Goltsev, Yury" sort="Goltsev, Yury" uniqKey="Goltsev Y" first="Yury" last="Goltsev">Yury Goltsev</name><name sortKey="Hwang, Peter H" sort="Hwang, Peter H" uniqKey="Hwang P" first="Peter H" last="Hwang">Peter H. Hwang</name><name sortKey="Jackson, Peter K" sort="Jackson, Peter K" uniqKey="Jackson P" first="Peter K" last="Jackson">Peter K. Jackson</name><name sortKey="Jackson, Peter K" sort="Jackson, Peter K" uniqKey="Jackson P" first="Peter K" last="Jackson">Peter K. Jackson</name><name sortKey="Jiang, Sizun" sort="Jiang, Sizun" uniqKey="Jiang S" first="Sizun" last="Jiang">Sizun Jiang</name><name sortKey="Kanie, Tomoharu" sort="Kanie, Tomoharu" uniqKey="Kanie T" first="Tomoharu" last="Kanie">Tomoharu Kanie</name><name sortKey="Kim, Dayoung" sort="Kim, Dayoung" uniqKey="Kim D" first="Dayoung" last="Kim">Dayoung Kim</name><name sortKey="Kim, Raymond" sort="Kim, Raymond" uniqKey="Kim R" first="Raymond" last="Kim">Raymond Kim</name><name sortKey="Lee, Ivan T" sort="Lee, Ivan T" uniqKey="Lee I" first="Ivan T" last="Lee">Ivan T. Lee</name><name sortKey="Lee, Ivan T" sort="Lee, Ivan T" uniqKey="Lee I" first="Ivan T" last="Lee">Ivan T. Lee</name><name sortKey="Mcilwain, David R" sort="Mcilwain, David R" uniqKey="Mcilwain D" first="David R" last="Mcilwain">David R. Mcilwain</name><name sortKey="Nakayama, Tsuguhisa" sort="Nakayama, Tsuguhisa" uniqKey="Nakayama T" first="Tsuguhisa" last="Nakayama">Tsuguhisa Nakayama</name><name sortKey="Nayak, Jayakar V" sort="Nayak, Jayakar V" uniqKey="Nayak J" first="Jayakar V" last="Nayak">Jayakar V. Nayak</name><name sortKey="Nolan, Garry P" sort="Nolan, Garry P" uniqKey="Nolan G" first="Garry P" last="Nolan">Garry P. Nolan</name><name sortKey="Overdevest, Jonathan B" sort="Overdevest, Jonathan B" uniqKey="Overdevest J" first="Jonathan B" last="Overdevest">Jonathan B. Overdevest</name><name sortKey="Overdevest, Jonathan B" sort="Overdevest, Jonathan B" uniqKey="Overdevest J" first="Jonathan B" last="Overdevest">Jonathan B. Overdevest</name><name sortKey="Patel, Zara M" sort="Patel, Zara M" uniqKey="Patel Z" first="Zara M" last="Patel">Zara M. Patel</name><name sortKey="Phillips, Katie M" sort="Phillips, Katie M" uniqKey="Phillips K" first="Katie M" last="Phillips">Katie M. Phillips</name><name sortKey="Schurch, Christian M" sort="Schurch, Christian M" uniqKey="Schurch C" first="Christian M" last="Schürch">Christian M. Schürch</name><name sortKey="Tyler, Matthew A" sort="Tyler, Matthew A" uniqKey="Tyler M" first="Matthew A" last="Tyler">Matthew A. Tyler</name><name sortKey="Tyler, Matthew A" sort="Tyler, Matthew A" uniqKey="Tyler M" first="Matthew A" last="Tyler">Matthew A. Tyler</name><name sortKey="Wu, Chien Ting" sort="Wu, Chien Ting" uniqKey="Wu C" first="Chien-Ting" last="Wu">Chien-Ting Wu</name><name sortKey="Yan, Carol H" sort="Yan, Carol H" uniqKey="Yan C" first="Carol H" last="Yan">Carol H. Yan</name><name sortKey="Yan, Carol H" sort="Yan, Carol H" uniqKey="Yan C" first="Carol H" last="Yan">Carol H. Yan</name><name sortKey="Yang, Angela" sort="Yang, Angela" uniqKey="Yang A" first="Angela" last="Yang">Angela Yang</name><name sortKey="Zarabanda, David" sort="Zarabanda, David" uniqKey="Zarabanda D" first="David" last="Zarabanda">David Zarabanda</name></country><country name="Japon"><region name="Région de Kantō"><name sortKey="Nakayama, Tsuguhisa" sort="Nakayama, Tsuguhisa" uniqKey="Nakayama T" first="Tsuguhisa" last="Nakayama">Tsuguhisa Nakayama</name></region></country><country name="Taïwan"><noRegion><name sortKey="Liao, Chun Kang" sort="Liao, Chun Kang" uniqKey="Liao C" first="Chun-Kang" last="Liao">Chun-Kang Liao</name></noRegion><name sortKey="Bau, Da Tian" sort="Bau, Da Tian" uniqKey="Bau D" first="Da-Tian" last="Bau">Da-Tian Bau</name><name sortKey="Bau, Da Tian" sort="Bau, Da Tian" uniqKey="Bau D" first="Da-Tian" last="Bau">Da-Tian Bau</name><name sortKey="Lin, Chia Der" sort="Lin, Chia Der" uniqKey="Lin C" first="Chia-Der" last="Lin">Chia-Der Lin</name><name sortKey="Lin, Chia Der" sort="Lin, Chia Der" uniqKey="Lin C" first="Chia-Der" last="Lin">Chia-Der Lin</name><name sortKey="Lin, Chia Der" sort="Lin, Chia Der" uniqKey="Lin C" first="Chia-Der" last="Lin">Chia-Der Lin</name><name sortKey="Lin, Chih Feng" sort="Lin, Chih Feng" uniqKey="Lin C" first="Chih-Feng" last="Lin">Chih-Feng Lin</name><name sortKey="Lin, Yi Tsen" sort="Lin, Yi Tsen" uniqKey="Lin Y" first="Yi-Tsen" last="Lin">Yi-Tsen Lin</name><name sortKey="Shih, Liang Chun" sort="Shih, Liang Chun" uniqKey="Shih L" first="Liang-Chun" last="Shih">Liang-Chun Shih</name><name sortKey="Shih, Liang Chun" sort="Shih, Liang Chun" uniqKey="Shih L" first="Liang-Chun" last="Shih">Liang-Chun Shih</name><name sortKey="Shih, Liang Chun" sort="Shih, Liang Chun" uniqKey="Shih L" first="Liang-Chun" last="Shih">Liang-Chun Shih</name><name sortKey="Tai, Chih Jaan" sort="Tai, Chih Jaan" uniqKey="Tai C" first="Chih-Jaan" last="Tai">Chih-Jaan Tai</name><name sortKey="Tai, Chih Jaan" sort="Tai, Chih Jaan" uniqKey="Tai C" first="Chih-Jaan" last="Tai">Chih-Jaan Tai</name><name sortKey="Tsai, Ming Hsui" sort="Tsai, Ming Hsui" uniqKey="Tsai M" first="Ming-Hsui" last="Tsai">Ming-Hsui Tsai</name><name sortKey="Tsai, Ming Hsui" sort="Tsai, Ming Hsui" uniqKey="Tsai M" first="Ming-Hsui" last="Tsai">Ming-Hsui Tsai</name><name sortKey="Tsai, Ming Hsui" sort="Tsai, Ming Hsui" uniqKey="Tsai M" first="Ming-Hsui" last="Tsai">Ming-Hsui Tsai</name><name sortKey="Tsay, Gregory J" sort="Tsay, Gregory J" uniqKey="Tsay G" first="Gregory J" last="Tsay">Gregory J. Tsay</name><name sortKey="Tsay, Gregory J" sort="Tsay, Gregory J" uniqKey="Tsay G" first="Gregory J" last="Tsay">Gregory J. Tsay</name><name sortKey="Tsou, Yung An" sort="Tsou, Yung An" uniqKey="Tsou Y" first="Yung-An" last="Tsou">Yung-An Tsou</name><name sortKey="Tsou, Yung An" sort="Tsou, Yung An" uniqKey="Tsou Y" first="Yung-An" last="Tsou">Yung-An Tsou</name><name sortKey="Yeh, Te Huei" sort="Yeh, Te Huei" uniqKey="Yeh T" first="Te-Huei" last="Yeh">Te-Huei Yeh</name><name sortKey="Yeh, Te Huei" sort="Yeh, Te Huei" uniqKey="Yeh T" first="Te-Huei" last="Yeh">Te-Huei Yeh</name></country><country name="Suisse"><noRegion><name sortKey="Tzankov, Alexandar" sort="Tzankov, Alexandar" uniqKey="Tzankov A" first="Alexandar" last="Tzankov">Alexandar Tzankov</name></noRegion><name sortKey="Matter, Matthias S" sort="Matter, Matthias S" uniqKey="Matter M" first="Matthias S" last="Matter">Matthias S. Matter</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/CovidStanfordV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000831 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000831 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= CovidStanfordV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:33116139
|texte= ACE2 localizes to the respiratory cilia and is not increased by ACE inhibitors or ARBs.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:33116139" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a CovidStanfordV1
| This area was generated with Dilib version V0.6.38. |  |